CT body composition, CPET and PET in OG cancer
Research type
Research Study
Full title
Association between CT body composition, CPET derived measures of physical fitness, and systemic inflammation in patients undergoing curative treatment for oesophagogastric cancers
IRAS ID
273027
Contact name
Stephen McSorley
Contact email
Sponsor organisation
NHS GG&C
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
The presence of an innate systemic inflammatory response in patients newly diagnosed with oesophagogastric cancer is recognised to be associated with poor prognosis independent of disease stage. Such host inflammatory responses are thought to contribute to the syndrome of cancer cachexia. Staging CT scans can be used to derive measures of lean body tissue mass and composition, such as skeletal muscle index and skeletal muscle radiodensity, which have been reported to be associated with both complications and survival after surgery for GI cancer. Cardiopulmonary exercise testing (CPET) is often used in patients prior to surgery for GI cancer to provide an objective measure of fitness and has also been reported to be associated with postoperative complications and mortality. It is unclear however, whether there is a direct relationship between these objective measures of muscle quantity and physical function in this group of patients. The aim of the proposed study is to assess the relationship between how active a tumour is (termed tumour metabolic activity using PET-CT, and levels of inflammation (using mGPS and NLR) with the loss of muscle (using CT) and the physical fitness / function of patients (using CPET), to survival in patients with oesophagogastric cancer treated with curative intent. This will be carried out by examining a prospectively maintained database of all patients with oesophagogastric cancer treated with curative intent in NHS Greater Glasgow and Clyde. CPET results, CT and PET-CT scans will then be retrospectively reviewed.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
19/SC/0653
Date of REC Opinion
7 Jan 2020
REC opinion
Favourable Opinion