CSF and blood collections for research

• Research type

  Research Tissue Bank

• IRAS ID

  194107

• Research summary

  Walton CSF Research Biobank

• REC name

  Wales REC 4

• REC reference

  16/WA/0291

• Date of REC Opinion

  18 Oct 2016

• REC opinion

  Further Information Favourable Opinion

• Data collection arrangements

  The Walton CSF Research Biobank (WCRB) collects and stores samples surplus to diagnostic requirements from
  neurology patients and healthy volunteers subject to fully informed consent. The samples collected are cerebrospinal fluid (csf), bloods including serum and plasma matched with patient demographics and
  clinical history. All the records are held in a secure database in the Walton Centre NHS Trust IT network.
  Samples are anonymised by biobank number before being released for research projects. All the research project
  applications are peer reviewed by senior clinicians,and researcher members of the WCRB management committee before release to researchers. Samples are also available to researchers outside WCRB but additional external REC ethical approval will be requested.

• Research programme

  The Walton CSF Research Biobank has been established to promote multidisciplinary basic and translational neurology research. Clinicians and basic science researchers in Liverpool and within the North West collaboration are actively engaged in neurology research to investigate molecular biomarkers that may be used to aid diagnosis and predict prognosis in neurological conditions and to gain an increased understanding of the basic biology of these diseases in order to develop better therapies for individual patients. Such research involves analysis of proteins, DNA, RNA, and metabolites from CSF and blood. Comparisons between sample biology, radiological imaging and clinical outcome are an essential component of this research. Our current areas of interest include paraneoplastic autoantibodies and their role in disease, method development to identify bio-markers present in both CSF and blood, the impact of molecular genetics and radiological parameters on outcomes in neurological conditions.

• Storage license

  12030

• RTBTitle

  Walton CSF Research Biobank

• Establishment organisation

  Walton Centre NHS Foundation Trust

• Establishment organisation address

  Lower Lane

  Fazakerley

  LIVERPOOL

  L9 7LJ