CRS in T1D
Research type
Research Study
Full title
Prevalence and consequences of Cardiorenal Syndrome (CRS) in type 1 diabetes patients among Scottish population
IRAS ID
329623
Contact name
Chim Lang
Contact email
Sponsor organisation
University of Dundee
Duration of Study in the UK
4 years, 3 months, 12 days
Research summary
Combined development of renal and cardiovascular complications is referred to as cardiorenal syndrome (CRS). The causes of development of CRS in T1DM are poorly understood. It has been suggested that endothelial dysfunction and atherosclerotic process may lead to simultaneous development and progression of renal and cardiac pathology, since endothelial dysfunction is already present at the early stages of T1DM. In this research fellowship/PhD, we aim to investigate the underlying mechanisms that are involved in changes in microvascular dysfunction (blood flow) among the patients of CRS when compared to healthy population, T1D patients, heart failure patients and chronic kidney disease patients. Specifically, vascular tests such as assessments of endothelial function using laser perfusion imaging with iontophoresis will be used along with the other CV clinical markers such retinopathy, neuropathy and nephropathy, echocardiography and renal venous congestion and blood borne metabolic and inflammatory markers will be performed.
REC name
London - Riverside Research Ethics Committee
REC reference
24/PR/0093
Date of REC Opinion
13 Feb 2024
REC opinion
Further Information Favourable Opinion