Cross sectional analyses of the CERTAIN registry cohort

• Research type

  Research Study

• Full title

  Immune response of paediatric renal transplant recipients challenged by sensitization, vaccination or non-adherence: Cross sectional analyses of the international Cooperative European Paediatric Renal TransplAnt INitiative (CERTAIN) registry cohort

• IRAS ID

  182582

• Contact name

  Nicholas Webb

• Contact email

  nicholas.webb@cmft.nhs.uk

• Sponsor organisation

  Manchester University NHS Foundation Trust

• Duration of Study in the UK

  3 years, 0 months, 0 days

• Research summary

  Chronic antibody mediated rejection (cAMR) is among the leading causes for long term graft failure with limited treatment options. The early identification of patients at risk for cAMR is of utmost importance and requires the identification and validation of non-invasive and specific biomarkers of impending cAMR. Utilising the CERTAIN registry (European web based paediatric renal transplant registry), a cohort of renal transplant patients with cAMR will be indentified. A blood and urine sample will be taken for the determination of diagnostic markers with the aim of identfiying new markers for cAMR and defining a prediction model for the occurrence of cAMR in renal transplant patients.

• REC name

  North West - Greater Manchester West Research Ethics Committee

• REC reference

  15/NW/0730

• Date of REC Opinion

  8 Sep 2015

• REC opinion

  Favourable Opinion