CROSS-HF
Research type
Research Study
Full title
CROSS sectional versus invasive imaging in patients with Heart Failure
IRAS ID
332073
Contact name
Peter Swoboda
Contact email
Sponsor organisation
University of Leeds
ISRCTN Number
ISRCTN12403403
Duration of Study in the UK
14 years, 5 months, 31 days
Research summary
Each year in the UK at least 60,000 patients are diagnosed with heart failure. Coronary artery disease (narrowing of the blood vessels supplying the heart) is the most common cause of heart failure. Invasive coronary angiography is often done as the first line test to identify coronary artery. However, we know from work with our patient and public involvement groups that most patients would prefer to avoid invasive coronary angiography if possible.
The aim of this trial is to establish if it is possible to reduce the need for invasive angiography in patients with newly diagnosed heart failure. 3000 patients presenting with a new diagnosis of heart failure and not known to have coronary artery disease will be recruited. They will be randomly assigned (equal chance) to one of three tests:
1. Invasive coronary angiogram (current NHS practice)- A specialised X-ray test where dye is injected directly into the heart arteries via the groin or wrist. It carries a small risk of serious complications such as stroke. The test exposes patients to radiation and is expensive. Furthermore, there are long waiting lists for the test following many cancellations due to the COVID-19 pandemic.
2. CT coronary angiography - this test is quick, non-invasive and cheaper than invasive angiography. It has a high accuracy for detection of coronary artery disease but can be challenging in certain patient groups such as elderly patients or those with irregular heart rhythms. It also exposes patients to a small dose of ionising radiation.
3. Stress cardiovascular MRI - This test is non-invasive and cheaper than invasive angiography and provides additional information on the structure and function of the heart. The accuracy of this test for detection of coronary artery disease is unproven in patients with heart failure. It does not expose patients to ionising radiation.REC name
West of Scotland REC 3
REC reference
24/WS/0108
Date of REC Opinion
12 Aug 2024
REC opinion
Further Information Favourable Opinion