CREED (alc hep)
Research type
Research Study
Full title
Changes in gut microbiota after enteral feeding (in alcoholic hepatitis)\n
IRAS ID
227760
Contact name
Ashis Mukhopadhya
Contact email
Sponsor organisation
Aberdeen Royal Infirmary
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Drinking large amounts of alcohol can cause damage to the liver. If the liver is severely injured by alcohol can become very inflamed. A severe inflammation of the liver caused by alcohol is called alcoholic hepatitis. Alcoholic hepatitis can be life threatening. Currently there is no available cure for alcoholic hepatitis. We however know that stopping drinking and taking good nutrition helps with the recovery. Medical intervention focuses on supporting other organs in the body while the liver inflammation hopefully settles. \n\nInfections are very common when the liver is inflamed by alcoholic hepatitis and when these infections are very severe they can affect recovery. It is not always possible to find out the origin of these infections. If some bowel bacteria move to the blood stream, they can be the cause of the infection. Illness like alcoholic hepatitis can cause “bad bacteria” to take over from “good bacteria” in the gut.\nThis study wants to understand the changes in the bacteria in the bowel of people who have alcoholic hepatitis. \nWe will take stool samples from patients admitted in the hospital with alcoholic hepatitis. We will run tests on the stools to be able to identify the gut bacteria. We think these bacteria will be different from the ones living in the bowel of healthy people. We are interested to see if these bacteria change once the patients are given good nutrition using a small tube from the nose to the stomach. Thus we will take some more stool samples at set times from these patients after the nutrition through the tube has started. \nWe have now more advanced tools to check the bacteria in the bowel so we will be able to understand if nutrition in alcoholic hepatitis can change bacteria in the bowel and therefore help recovery in alcoholic hepatitis.\n\n
REC name
North of Scotland Research Ethics Committee 2
REC reference
19/NS/0097
Date of REC Opinion
10 Jul 2019
REC opinion
Further Information Favourable Opinion