CRAAFT-HF

• Research type

  Research Study

• Full title

  CRAAFT-HF: Cryoballoon/Radiofrequency Ablation of Atrial Fibrillation versus Medical Treatment for Heart Failure

• IRAS ID

  281142

• Contact name

  Pushpsen Joshi

• Contact email

  uclh.randd@nhs.net

• Sponsor organisation

  University College London

• Clinicaltrials.gov Identifier

  NCT06505798

• Clinicaltrials.gov Identifier

  UCL Data Protection Registration-Health Research , Z6364106/2024/01/68

• Duration of Study in the UK

  6 years, 6 months, 0 days

• Research summary

  Atrial fibrillation (AF) is a common heart rhythm disorder that causes an irregular heart beat and is a cause of heart failure (HF). Treatments include drugs to slow the heart rate, anti-arrhythmic drugs or ablation of the heart to help preserve normal rhythm. A number of trials have suggested that ablation may be superior to drug treatment to reduce hospitalisations or prevent early death. However, these studies have been small and the results not applicable to the general population with AF and heart failure in the UK. This international study will compare optimal medical therapy with catheter ablation versus optimal medical therapy alone to see if catheter ablation reduces unplanned heart failure hospitalisations and death rates and improves quality of life.

• REC name

  London - Hampstead Research Ethics Committee

• REC reference

  24/LO/0301

• Date of REC Opinion

  23 May 2024

• REC opinion

  Further Information Favourable Opinion