CPS-Facilitating catheter guidance to optimal site for VT ablation V1
Research type
Research Study
Full title
Cardiac Positioning System (CPS) - A navigation system to guide pace mapping of ischemic scar during catheter ablation therapy of post-myocardial infarction (MI) ventricular tachycardia (VT) in adults.
IRAS ID
253560
Contact name
Yolanda Hill
Contact email
Sponsor organisation
University of Exeter
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 4 months, 14 days
Research summary
The lack of oxygen to the heart during a heart attack causes scar tissue to form on the myocardium. Electrical activation waves which drive contraction become disrupted by the scarring and can set up reentrant circuits circling around the scar, overriding the natural rhythm of the heart. The abnormal rhythm, ventricular tachycardia, causes the heart to beat faster than normal and can result in sudden cardiac death. One of the strategies to treat this condition is radio-frequency catheter ablation which aims to disrupt the reentrant circuit. The difficulty lies in detecting the optimal site to deliver the therapy. The pace mapping technique relies on comparing electrocardiogram recordings of the tachycardia with electrocardiograms during stimulation via a catheter placed at a particular location within the heart. If the electrocardiograms match, therapy is delivered to the site of stimulation. If not, the catheter is moved around until a match is found. This can result in long procedure times requiring very skilled cardiologists and potentially, delivery of the therapy to an inadequate site. The aim of this study is to develop a methodology to accurately direct the catheter to subsequent stimulation locations in real-time, speeding up the procedure, increasing therapy safety and success. We will collect patient demographic data, along with electrocardiogram, stimulation location and successful ablation location data from 60 patients over a period of 12 months. Patients will have post-myocardial infarction ventricular tachycardia, and require radio-frequency catheter ablation therapy. There will be no change to standard procedure other than some extra measurements being taken, adding no more than 5 minutes to the procedure. Patient recruitment and data collection will be carried out at Bristol Heart Institute and data will be analysed at the University of Exeter. This study is funded by a grant from the Medical Research Council.
REC name
South Central - Oxford C Research Ethics Committee
REC reference
19/SC/0376
Date of REC Opinion
26 Jul 2019
REC opinion
Favourable Opinion