CPPOpt Guided Therapy; Assessment of Target Effectiveness and Safety
Research type
Research Study
Full title
A randomized clinical trial assessing the effect of “optimal” cerebral perfusion pressure monitoring in the management of severe traumatic brain injury
IRAS ID
219952
Contact name
Ari Ercole
Contact email
Sponsor organisation
Clinical Trial Center Maastricht (CTCM)
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
In the hours and days following a severe traumatic brain injury, the patient is vulnerable to further brain damage caused by abnormalities in brain blood flow causing alterations in the delivery of oxygen and nutrients. Therefore, a focus of patient management on the neurocritical care unit, is to monitor and prevent abnormalities in the brain blood flow.
One of the primary techniques employed in the management of these patient’s brain blood flow is monitoring and manipulating the pressure that drives brain blood flow – the cerebral perfusion pressure (CPP). This is calculated simply as the arterial blood pressure minus the pressure within the skull and is a standard approach in critical care units.
However, which level of CPP is best for each particular patient is currently unknown. In fact, current guidelines indicate the same level of CPP for every patient. This research aims to provide the treating medical team with guidance as to what CPP should be aimed for in a brain trauma patient throughout their time on the critical care unit. The technique uses a computerized analysis of the patients’ brain vessel function and CPP to suggest the ‘optimal’ CPP (CPPopt).
The purpose of this study are to assess the feasibility and safety of targeting CPPopt compared to standard CPP management.REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
17/LO/1119
Date of REC Opinion
30 Oct 2017
REC opinion
Further Information Favourable Opinion