CPP-ACP toothpaste trial v1.1
Research type
Research Study
Full title
An in situ study to determine the effects of Casein phosphopeptide-amorphous calcium phosphate toothpaste in orthodontic patients
IRAS ID
128420
Contact name
Norah Flannigan
Contact email
Sponsor organisation
University of Liverpool
Research summary
The purpose of the study is to assess if the use of calcium based toothpastes are better at repairing white spots on teeth than fluoride based toothpastes. Marking and white spots on teeth are a known side effect of orthodontic treatment and can be the beginning of tooth decay. Research has shown conflicting evidence on the effectiveness of Calcium based toothpastes. Laboratory based experiments have shown a limited effect on preventing damage to the tooth surface, however clinical research in people has shown a beneficial effect (Bailey et al 2009)
This study will involve the use of sterilised human tooth specimens being attached to a fixed brace in patients receiving orthodontic treatment. The patient will then be provided with two different commercially available toothpastes and instructed on its use for a period of 1 month. The tooth specimen will then be removed and analysed in a laboratory to assess its effectiveness in preventing tooth surface damage.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
13/NW/0742
Date of REC Opinion
11 Nov 2013
REC opinion
Favourable Opinion