CPEXtubate
Research type
Research Study
Full title
Investigating the ability of cardiopulmonary exercise markers to predict successful extubation in intensive care (CPEXtubate)
IRAS ID
270026
Contact name
John Michael Bramwell
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
We aim to research whether cardiopulmonary exercise testing (CPET) equipment can help doctors decide if intensive care patients are ready to breathe without the support of mechanical ventilation. When patients are very ill they often can no longer manage to breathe adequately and so they have a tube placed into their airway and through this are mechanically ventilated. Once they have recovered enough, the support from the ventilator is gradually reduced, until eventually their breathing tube can be removed (called extubation). This process can be very difficult, because the patients may now be very weak and have poor lungs and be unable to manage without the ventilator. Patients in this situation are at increased risk of death. Predicting the optimum time for extubation is therefore vital. CPET equipment is used in other fields of medicine to determine how tiring a patient finds exercise and to predict how they would cope with major surgery. Breathing without support from a ventilator is exercise for a patient recovering from a critical illness. We believe CPET type measurements can be used to reduce the number of patients who need to be reventilated by more accurately predicting who can cope without the ventilator. CPET will assess how strenuous they are finding the exercise of breathing during a period of minimal support from the ventilator. This period is referred to as a spontaneous breathing trial (SBT) and is currently used in this role with simple measurements.
Participants will be intensive care patients at the Northern General Hospital who have been mechanically ventilated and are being assessed for extubation. Participants would have the CPET equipment connected to their breathing tube before and during their SBT, then they would be followed up during their hospital stay. We anticipate the study will run for 1-2 years to recruit 100 patients.
REC name
Social Care REC
REC reference
19/IEC08/0059
Date of REC Opinion
14 Jan 2020
REC opinion
Further Information Favourable Opinion