CPET and stress echocardiography following pulmonary embolism
Research type
Research Study
Full title
Utility of cardiopulmonary exercise testing and stress echocardiography in the assessment of breathlessness following pulmonary embolism: a pilot study
IRAS ID
300840
Contact name
Colm McCabe
Contact email
Sponsor organisation
Royal Brompton Hospital
Duration of Study in the UK
0 years, 11 months, 31 days
Research summary
Pulmonary embolism (PE) is a common, potentially life-threatening, condition with up to 50% of PE survivors developing long-term complications. These complications include post-PE syndrome and pulmonary hypertension, which are associated with breathlessness, functional limitation and risk of premature death if not diagnosed and treated promptly. This project aims to better understand the contributing factors to persistent breathlessness after PE and investigate the utility of non-invasive exercise testing for early detection of potential causes of post-PE syndrome. This prospective pilot observational study will recruit 20 patients and systematically perform the follow-up assessments as part of routine NHS care, as well as undertake a limited echocardiogram during a cardio-pulmonary exercise test. Incorporating echocardiography with exercise tests in the follow-up of patients with PE is a novel screening approach not previously evaluated in this disease spectrum.
REC name
Wales REC 5
REC reference
21/WA/0230
Date of REC Opinion
26 Aug 2021
REC opinion
Further Information Favourable Opinion