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COVID-HEART study [COVID-19] [UPH]

  • Research type

    Research Study

  • Full title

    Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: the COVID-HEART study

  • IRAS ID

    285147

  • Contact name

    John Greenwood

  • Contact email

    j.greenwood@leeds.ac.uk

  • Sponsor organisation

    University of Leeds

  • ISRCTN Number

    ISRCTN58667920

  • Duration of Study in the UK

    1 years, 0 months, 0 days

  • Research summary

    Up to 1 in 5 patients hospitalised by COVID-19 have evidence of heart muscle injury as measured from a blood test. This is associated with a high death rate. Using a magnetic resonance imaging(MRI) scan (a type of scan that uses strong magnetic fields and radio waves to produce detailed images of the inside of the heart) we will look at how often, and in what way, the heart becomes damaged, and how the heart recovered 6 months later. We need to know how heart muscle damage and recovery is affected by age, sex, ethnic group and other medical conditions (such as diabetes, high blood pressure, heart disease and narrowing of blood vessels), as these are also known to be associated with high death rates. We also want to see if we can improve the diagnosis of viral heart damage from a simple electrocardiogram (ECG) (a test that is used to check the heart’s rhythm and electrical activity). This could save patients having invasive heart tests which can be uncomfortable, are expensive and carry a small risk of serious complications and may put healthcare staff at increased risk of exposure to COVID-19.\nWe have established a large group of leading UK academic centres which have committed to work together. Recruitment will be linked to the Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes (P-HOSP:COVID-19 Study) which aims to recruit 10,000 patients, 5000 of whom we aim to recruit to these additional research procedures including imaging.

  • REC name

    North West - Greater Manchester South Research Ethics Committee

  • REC reference

    20/NW/0292

  • Date of REC Opinion

    30 Jun 2020

  • REC opinion

    Further Information Favourable Opinion