COSTrans-MDRGNB
Research type
Research Study
Full title
Core Outcome Set in Infection Prevention and Control Trials for prevention of Transmission of MDRGNB (COSTrans-MDRGNB) study
IRAS ID
305160
Contact name
Razan Saman
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Antibiotics may not be effective at treating an infection caused by a resistant bacteria or superbug. A particular type of superbug, multi-drug resistant gram-negative bacteria (MDRGNB) are more likely to cause outbreaks in healthcare environments, and are causing an increasing number of deaths every year. To help prevent the spread of superbugs hospitals implement infection prevention (IP) procedures e.g. hand washing and single rooms. IP procedures are designed to stop the spread of superbugs and prevent harm caused by infection to patients and health workers.
To help patients and doctors make decisions about IP procedures, we need evidence about what works best. IP procedures are developed and tested by researchers to make sure they work and are safe. Researchers do this by looking at the effects those procedures have on patients by measuring an ‘outcome’. Clinical studies have compared various interventions to prevent the spread of superbugs. However, such studies often do not address the same outcomes, making it difficult to draw conclusions. If all studies in IP used the same outcomes, they could all be compared and combined. When a set of main outcomes has been agreed for a health condition, it’s called a ‘core outcome set’ (COS). Core outcomes have to be relevant to patients, carers and health professionals. This is done by ensuring that the expertise from patients, carers and professionals is used to agree on the core outcomes, using a ‘consensus method’.
This study will develop a COS for IP studies of MDRGNB. The study will involve a consensus method (surveys, meetings and discussions) for a period of 6-12 months where the opinions of relevant experts and patients are drawn together. The study is funded by Healthcare Infection Society and will be carried out in Leeds Teaching Hospitals NHS Trust.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
22/EM/0034
Date of REC Opinion
2 Mar 2022
REC opinion
Further Information Favourable Opinion