Cortical Excitability in Neurological Genetic Conditions
Research type
Research Study
Full title
Cortical excitability in subjects with genetic neurological disorders, a Transcranial Magnetic Stimulation study.
IRAS ID
170453
Contact name
William Stern
Contact email
Sponsor organisation
UCL
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
This study will use Transcranial Magnetic Stimulation (TMS), a well-established non-invasive and safe technique, to study brain excitability in people with a variety of genetic neurological conditions. We know that different TMS paradigms can measure the effects of different brain circuits, some of which are excitatory and some of which are inhibitory. In genetic conditions where we know which brain component is affected, we believe TMS can be used to measure the effect of the condition on how the brain is working, and provide valuable extra information to researchers trying to understand and treat these conditions better. Comparing these individuals with control subjects may also provide insight into normal brain physiology.
REC name
London - South East Research Ethics Committee
REC reference
15/LO/1642
Date of REC Opinion
24 Nov 2015
REC opinion
Further Information Favourable Opinion