Correlation of pre- and post-operative cancer imaging techniques
Research type
Research Study
Full title
Pilot study: correlation of pre-operative cancer functional imaging techniques with post-operative histology slides
IRAS ID
287316
Contact name
Stephen Marshall
Contact email
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 11 months, 31 days
Research summary
Information is derived from imaging such as high resolution CT and FDG PET scans prior to deciding on radical cancer treatment. However, it is not known what is happening at a cellular level from these images. That is, just from observing the PET/CT signal we cannot differentiate substructures in the tumour environment.
Ultimately we want to use this study to correlate the pathological specimen with PET images so that we can get a better understanding of the pathological information within different regions of a tumour and its relationship with the 18F FDG PET image.
To date, our project has successfully fused pre-operative in vivo CT image of the tumour with the resected pathological specimen. The aim of this next project is to register the pre-resected in vivo 4D 18 F FDG PET image with the macro and microscopic resected lung cancer.
If we manage to better understand the tumour pathological environment and its relationship to the PET images we may be able to harness this information to adapt and individualise radiotherapy treatment in patients who are not undergoing surgical resection of their tumour. In addition, this may provide us with prognostic predictive pretreatment signals to either intensify or de-escalate treatment.REC name
North West - Preston Research Ethics Committee
REC reference
21/NW/0088
Date of REC Opinion
9 Jun 2021
REC opinion
Further Information Favourable Opinion