Coronary Disease in Heart Failure with Preserved Ejection Fraction
Research type
Research Study
Full title
A prospective study quantifying the burden of coronary artery disease and myocardial ischaemia in an unselected cohort of patients with heart failure with preserved ejection fraction admitted to hospital with decompensated heart failure. (CorPEF)
IRAS ID
151968
Contact name
Christopher J Rush
Contact email
Sponsor organisation
NHS Greater Glasgow & Clyde
Duration of Study in the UK
2 years, 6 months, 0 days
Research summary
Heart failure with preserved ejection fraction (HF-PEF) accounts for half of patients with heart failure. Patients with HF-PEF have poor outcomes and these have not improved in over two decades. The underlying causes are not well understood and no treatments have been shown to improve symptoms or life expectancy in HF-PEF.
A lack of blood getting to the heart muscle, known as myocardial ischaemia, may cause HF-PEF, or contribute to the poor outcomes associated with HF-PEF. The most common cause of myocardial ischaemia is thought to be narrowings of the large heart arteries which supply blood to the heart muscle, known as coronary artery disease (CAD). The prevalence of CAD (how common it is) has never been described in a real world group of patients with HF-PEF. Myocardial ischaemia may also be caused by abnormalities of the small heart arteries, a problem known as coronary microvascular dysfunction (CMD). In patients with HF-PEF and CAD and/or CMD, improving blood flow to the heart muscle might improve symptoms and life expectancy.
This aim of this study is to assess the prevalence of CAD and CMD, their severity and their consequences (severe enough to restrict blood flow to the heart muscle?) in a real world group of patients with HF-PEF. This study will aim to investigate near-consecutive patients admitted to the Queen Elizabeth University Hospital and Glasgow Royal Infirmary with HF-PEF. 150 patients will be recruited and undergo special heart scans (cardiac magnetic resonance imaging) and heart artery dye tests (coronary angiography) with measurement of blood flow in the heart arteries (pressure wire studies). With this information, we hope to identify patients who, in the future, might benefit from treatment which could improve symptoms and life expectancy in a condition with poor outcomes and no current effective treatment options.
REC name
West of Scotland REC 4
REC reference
16/WS/0111
Date of REC Opinion
29 Jul 2016
REC opinion
Further Information Favourable Opinion