Corneal sensation after endocytophotocoagulation
Research type
Research Study
Full title
Assessing the Effect of Endocytophotocoagulation to Corneal Nerve and Sensation
IRAS ID
207588
Contact name
Deepa Anijeet
Contact email
Sponsor organisation
Clinical Research & Development, Greater Glasgow & Clyde
Clinicaltrials.gov Identifier
GN16OP349, R&D reference
Duration of Study in the UK
1 years, 0 months, 4 days
Research summary
Our main hypothesis is that endocytophotocoagulation during pars plana vitrectomy affects the corneal nerve function. The study aims to:
1. Identify and quantify corneal sensory nerve function before and after endocytophotocoagulation during pars plana vitrectomy for various indications.
2. Determine if diabetic patients undergoing endocytophotocoagulation during pars plana vitrectomy have a greater degree of corneal sensory loss compared to non-diabetic patients.
Background:
Corneal nerve supply is from ophthalmic branch of the trigeminal nerve, via ciliary nerves. Damages to short and long ciliary nerves have been shown following transcleral cyclodiode laser, encircling band for retinal detachment and circumferential endolaser that results in neurotrophic keratopathy. Corneal sensitivity reduction after argon retinal laser had been previously reported by other investigators. Some severe cases of retinal laser induced internal ophthalmoplegia have also been reported.The other association with corneal sensory changes is diabetes. Diabetic patients show changes in unmyelinated C-class and Ad small nerve fibres in presence of diabetic peripheral neuropathy. Symptoms include hyperesthesia, paraesthesia, and loss of pain and temperature sensation. Small corneal nerve fibres have also been shown to be affected from early stages.
REC name
Wales REC 7
REC reference
16/WA/0313
Date of REC Opinion
4 Nov 2016
REC opinion
Further Information Favourable Opinion