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Corneal imaging to monitor disease progression and/or treatments

  • Research type

    Research Study

  • Full title

    Corneal imaging and densitometry measurements to monitor disease progression and/or treatments outcomes



  • Contact name

    M Chantal Hillarby

  • Contact email

  • Sponsor organisation

    University of Manchester

  • Duration of Study in the UK

    2 years, 5 months, 1 days

  • Research summary

    The main purpose of this study is to determine if corneal clarity measurements may improve the management of corneal disease. The aim is to use corneal clarity measurements derived by new densitometry software for analysing Oculus Pentacam images. These images are already part of routine assessment of corneal disease but the new software allows clarity to be assesses. This may help to determine corneal disease progression, severity and treatment outcome.
    We aim to use this software to assess corneal clarity in in health and disease. In diseases that involve the loss of the corneal endothelium, there is an increasing reduction in corneal clarity, which may reach a point where a corneal graft may be beneficial. At present, there are no methods that give a numerical measurement of clarity that can be used along with other indicators of when a graft would improve vision, therefore, Corneal densitometry measurements may help determine when surgery is needed. Several types of corneal transplants are available and following patients post-surgery may shed light on which type of transplant gives the best corneal clarity.
    We will also apply these measurements to other corneal treatments such as refractive surgery and corneal cross-linking to determine treatment outcome.

  • REC name

    North East - York Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    23 Oct 2015

  • REC opinion

    Favourable Opinion