CoReCCT
Research type
Research Study
Full title
Confederation of Respiratory Critical Care Trials
IRAS ID
335630
Contact name
Danny McAuley
Contact email
Sponsor organisation
University of Warwick
ISRCTN Number
ISRCTN63784375
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
CoReCCT (the Confederation of Respiratory Critical Care Trials) has been established as a novel concept to group a range of respiratory critical care trials, with an overarching aim to streamline trial delivery across areas such as governance, contracting, and data collection. The overriding objective is to improve deliverability by minimising burden on participating sites and participants.
The primary aim of the clinical trials (domains) within CoReCCT is to test the clinical and cost effectiveness of four interventional strategies on the patient outcomes in hospitalised adults with moderate to severe acute respiratory failure that may require tracheal intubation and mechanical ventilation support.
The interventional strategies are presented as a series of clinical trials (domains), which occur both sequentially and concurrently along the clinical care pathway of a patient with moderate to severe acute respiratory failure. These domains include the Awake Prone Study (pre-intubation), PROTECT Airways trial (intubation), RELEASE trial and NAVA trial (both post-intubation).
REC name
Wales REC 2
REC reference
24/WA/0128
Date of REC Opinion
9 Jul 2024
REC opinion
Further Information Favourable Opinion