Cord blood B-cell precursors acute lymphoblastic leukaemia
Research type
Research Study
Full title
Use of B-cell precursors from cord blood to model hereditary predisposition to acute lymphoblastic leukaemia.
IRAS ID
249951
Contact name
James Studd
Contact email
Sponsor organisation
Institute of Cancer Research
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
Acute lymphoblastic leukaemia (ALL) is a disease of blood cells called B-cells. B-cell are a component of the immune system. In ALL B-cells do not develop normally, they acquire abnormal properties allowing them to grow in a uncontrolled way, becoming cancerous. Siblings of children with ALL are more likely to develop the disease, demonstrating that your genes play a role in the disease. Some people have a higher risk of developing the disease because of their genes. Cord blood is rich in B-cells providing a valuable resource to model the disease process. B-cells in cord blood will be isolated and manipulated to recreate the genes of people at high risk developing ALL. These cells will be studied in the laboratory to investigate how these modifications effect their cancer like properties. The aim of the study is to understand how your genes influence the risk of developing disease.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
18/SC/0394
Date of REC Opinion
18 Jul 2018
REC opinion
Favourable Opinion