CorCMR
Research type
Research Study
Full title
The Clinical Utility Of Cardiac Magnetic Resonance Imaging in Patients With Angina But No Obstructive Coronary Disease (CorCMR): A Diagnostic Study And Nested Randomised Trial.
IRAS ID
281128
Contact name
Colin Berry
Contact email
Sponsor organisation
Golden Jubilee National Hospital National Waiting Times Board
Clinicaltrials.gov Identifier
Duration of Study in the UK
19 years, 11 months, 31 days
Research summary
Angina is usually thought to be due to blockages in the main blood vessels in the heart. Recent research has found that fewer than 1 in 2 patients with angina have blocked heart arteries. In the other patients, small vessel problems may be relevant.
The NHS standard test for patients with angina is a coronary angiogram. This test is done by a doctor and involves passing dye into the heart blood vessels to look for blockages. The small vessels are thinner than a human hair and cannot be seen by the doctor, so information on small vessel problems is usually not assessed. Patients who may have angina due to small vessel problems may be mis-diagnosed.
MRI can assess blood flow in the heart. It is not known whether MRI might be useful to assess for abnormal blood flow due to small vessel problems and MRI is not used in NHS Scotland for this purpose. Our research study aims to clarify whether or not MRI would be useful to diagnose small vessel problems.
In patients with angina in whom the angiogram is clear, we will assess whether MRI for blood flow after an angiogram would change the diagnosis and treatment and if so, whether this leads to improvements in longer term wellbeing, quality of life and NHS resource use, or not. All patients will have a standard MRI report but since the blood flow part of MRI is not standard, this aspect will be used in half of the patients to guide care whereas standard care will apply in the other half.REC name
West of Scotland REC 4
REC reference
20/WS/0159
Date of REC Opinion
7 Jan 2021
REC opinion
Further Information Favourable Opinion