COPTIC-2
Research type
Research Study
Full title
Evaluating the diagnostic accuracy of novel organ injury biomarkers in adult cardiac surgery
IRAS ID
293173
Contact name
Gavin J Murphy
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Organ injury and problems with the kidney, heart and lungs after heart surgery are not uncommon and caring for patients who develop these issues takes a lot of resources.
Progress towards preventing these problems is difficult because we don't fully understand the reasons why they happen.
Cardiopulmonary bypass (CPB) during surgery is thought to be a cause, along with how generally healthy the patient is going into the surgery, but this is difficult to predict as there are lots of health problems that people can have.
But we think that these different kinds of health problems are what is behind the differences we see in how people are affected by organ injury as a result of their heart operation. These may also be the reason why treatments to prevent organ injury have a different effect in animal studies compared to humans.
And so, by learning more about these different health problems, we think that we can group patients more accurately and develop ways to prevent organ injury in a more personal way.
The aim of this study is to investigate how accurately we can predict organ injury in patients having a heart operation using measurements within the body called biomarkers along with clinical research data about their health.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
21/SC/0118
Date of REC Opinion
29 Mar 2021
REC opinion
Favourable Opinion