CONUS-BRS
Research type
Research Study
Full title
An observational, analytical, cross sectional study investigating the effects of Conus branch and Right Ventricular Branch occlusion on surface ECG and intra-cardiac electrograms in patients undergoing percutaneous coronary intervention (PCI).\n
IRAS ID
211163
Contact name
Pier Lambiase
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Brugada syndrome is an uncommon heart condition that can result in abnormal heart rhythms, called arrhythmias, which can be fatal. The underlying cause of Brugada is thought to be due to genetic mutations, however not all Brugada patients have these mutations and there is some uncertainty as to how and why the abnormal electrical patterns in the heart are caused. Previous case studies have reported temporary electrical changes recorded by electrocardiograms (ECGs) characteristic of Brugada syndrome during the obstruction of blood flow into certain branches of the artery that supplies blood to the right side of the heart. Further investigation is warranted to document and measure the effects of this in more detail. \nDuring routine procedures whereby chronic blockages of the heart arteries are opened, a small balloon on a wire is sometimes inflated into the branches of the artery being treated; this effectively obstructs the blood flow. We propose to measure the electrical changes at key areas of the heart by inserting a specially designed catheter that is able to record small electrical signals into the right heart chamber whilst also connecting the balloon wire to a recording system. The signals from both the balloon wire and the catheter will give us in depth information to be able to devise whether any electrical changes occur that may be characteristic of Brugada, which would help identify the mechanism behind Brugada Syndrome. \n
REC name
London - South East Research Ethics Committee
REC reference
18/LO/0220
Date of REC Opinion
11 Sep 2018
REC opinion
Further Information Favourable Opinion