Control samples for T1D genotype & T-cell phenotype study (Version 1)
Research type
Research Study
Full title
The consequence of genetic variants associated with type 1 diabetes (T1D) on immune cell function in healthy individuals.
IRAS ID
193754
Contact name
Kathleen M Gillespie
Contact email
Duration of Study in the UK
4 years, 1 months, 16 days
Research summary
Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin producing cells in the pancreas. Individuals with T1D are treated with daily insulin replacement injections. Genetic and immunology studies indicate that future therapies targeting the immune system are most likely to result in prevention of the condition but targeted modulation of the immune system will require better understanding of the pathogenesis of the disease. Previous studies by other research groups have shown that genetic variants associated with type 1 diabetes effect the function of immune cells even in healthy individuals. Of particular interest are CD4+ T-cells because a subset of these cells are able to regulate the activity of other immune cells. Defects in this regulation may contribute to the pathogenesis of type 1 diabetes.
In this study we will analyse a range of different immune cell functions that can be measured in a laboratory using immune cells extracted from blood. We will compare these measures in healthy individuals with different genetic variants.
REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
15/NW/0966
Date of REC Opinion
8 Dec 2015
REC opinion
Favourable Opinion