Contrast Enhanced Ultrasound, Endoleak Detection following EVAR v1.3
Research type
Research Study
Full title
Contrast Enhanced Ultrasound Endoleak Detection Compared To Time-Resolved Computer Tomography Angiography in high risk Endovascular Aneurysm Repair (EVAR) surveillance patients.
IRAS ID
185517
Contact name
Srinivasa Vallabhaneni
Contact email
Sponsor organisation
Royal Liverpool & Broadgreen Hospitals NHS Trust
Duration of Study in the UK
1 years, 9 months, 0 days
Research summary
Is Contrast enhanced Ultrasound as accurate in the detection of endoleaks as time-resoled Computer Tomographic Angiography in high risk Endovascular Aneurysm Repair (EVAR) surveillance patients?\n\nEVAR is used as the ’keyhole’ alternative to open surgery for a dilated artery (aneurysm) within the abdomen. It involves placing a metal and fabric stent within the aneurysm to carry the blood and related pressure through the center of the aneurysm, so preventing the rupture of the aneurysm. \nEVAR has a lower risk of death associated with the initial operation compared to open surgical repair but requires ongoing surveillance/monitoring to prevent later complications. \nIt is still to be fully established the best type of scan to undertake this surveillance.\nComputer Tomography Angiography (CTA) has been heralded as the ’gold standard’ however previous studies into Contrast Enhanced Ultrasound (CEUS) seem to suggest it has a higher accuracy than CTA. We hope to establish the true accuracy of CEUS by comparing it to ’time resolved’ CTA (tCTA), which has been shown to be superior to standard CTA in recent studies.\nParticipants will be recruited from the Liverpool Vascular & Endovascular service ultrasound surveillance program, based at the Royal Liverpool Hospital. They will be invited to participate if they have findings suggestive of the complication being investigated. They will then undergo a CEUS and tCTA instead of their normal care (CEUS & CTA). Participants will have both scans performed on the same day. Following the scans these participants will return to standard care under their normal team.\nThis will provide a set of paired diagnostic images that we can use to calculate the accuracy of CEUS compared to tCTA.
REC name
North West - Preston Research Ethics Committee
REC reference
15/NW/0908
Date of REC Opinion
8 Dec 2015
REC opinion
Further Information Favourable Opinion