Construction of VOC profile of FAP,Polyposis and Colon cancer patients
Research type
Research Study
Full title
Pilot phase study Formulating Volatile organic compounds profile of FAP and Colon cancer patients
IRAS ID
129154
Contact name
Omar Faiz
Contact email
Sponsor organisation
North West London Hospitals Trust
Research summary
Bowel cancer is one of the leading causes of cancer deaths accounting for 15708 deaths in the year 2010 in UK. Current screening modalities such as FOBT (Faecal occult blood test) have got low sensitivity, specificity and positive predictive value (Niv Y, 1995 Nov). Hence we would like to enhance the sensitivity and specificity of screening tests for colon cancer by exploring novel non-invasive screening techniques.
Familial adenomatous polyposis (FAP) is an inherited disorder characterised by hundreds / thousands of polyps in the Colon, rectum and duodenum which may develop into cancer (adenoma-carcinoma sequence) at later stage. The analysis of volatile organic compounds (VOCs)within breath that are linked to cancer is a new frontier in medical diagnostics because it is non-invasive and potentially inexpensive.
This study will analyse exhaled breath of known colon cancer and familial adenomatous polyposis patients to identify compounds that may be present in both groups.We will also recruit healthy volunteers who have no evidence of any cancer and have normal endoscopy to act as controls.REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
13/YH/0326
Date of REC Opinion
24 Oct 2013
REC opinion
Further Information Favourable Opinion