Construction of pre-operative outcome prediction model using CPET
Research type
Research Study
Full title
Construction of pre-operative outcome prediction model and its use in gynaecological oncology using cardiopulmonary exercise testing harnessed to spectrochemical analysis of biofluids.
IRAS ID
254380
Contact name
Nicholas Wood
Contact email
Sponsor organisation
Lancashire Teaching Hospitals NHS Foundation Trust
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
2 years, 5 months, 18 days
Research summary
The aim of the study is to produce a pre-operative outcome prediction model for gynaecological oncology patients. Patients over the age of 65 or who have two or more comorbidities currently undergo a cardiopulmonary exercise test (CPET) prior to surgery. The test is performed to guide the team with how well the patient would cope with the stresses of major surgery. It helps plan the patient’s care and guide whether things such as HDU support would be required postoperatively.
The pre-operative prediction model would be created using retrospective data from 2011 onwards currently available from previous CPET studies and information from the electronic patient records for gynaecological oncology patients previously cared for by the trust. At this stage there would be no exclusion criteria except age below 18 years and all others who underwent CPET would be included.
The model would then be tested for sensitivity and specificity and used on a cohort of prospective gynaecological oncology patients.
Whilst the model will be tested on patients undergoing CPET, patient serum, urine and saliva samples will also be taken. These biological samples will also be analysed using spectroscopy to assess if they can be used or incorporated into the model to improve patient outcome following oncological surgery in gynaecology patients.
The hope is to create a prediction model that would guide clinicians which patients would need further care such as HDU, give an idea of length of stay whilst in hospital, predict mortality or common complications associated with surgery without having to undergo a CPET. This would ultimately improve patient care and also be a significant reduction in cost for the trust. It would be time and cost effective, as well as giving patients a more personalised approach to their care.REC name
North West - Preston Research Ethics Committee
REC reference
19/NW/0280
Date of REC Opinion
23 Jul 2019
REC opinion
Further Information Favourable Opinion