Connexin-mediated signalling events in the pathogenesis of psoriasis.
Research type
Research Study
Full title
Connexin-mediated signalling events in the pathogenesis of psoriasis.
IRAS ID
189093
Contact name
Mozheh Zamiri
Contact email
Sponsor organisation
NHS Ayrshire and Arran
Duration of Study in the UK
2 years, 11 months, 30 days
Research summary
During psoriasis, skin cells multiply and their ability to stick to one another is affected, resulting in "flaky" skin and inflammation. A change in the bacteria that live on the surface of the skin during psoriasis may also influence this process. We will investigate how a family of proteins, the connexins, that enable skin cells to i) talk to one another and ii) stick to one another are modified during psoriasis and by microorganisms present on the skin. Connexin26 is found at very high levels in the skin of psoriasis patients yet the level of its sister protein Connexin43 is reduced. Agents that can 'block' overactive Connexin26 may decrease inflammation, and agents that stabilise Connexin43 may encourage skin cells to stick together thereby reducing the symptoms of psoriasis. Skin cells isolated from 'normal' and 'psoriatic' skin samples will be used. Such an approach may identify new treatments for psoriasis.
REC name
West of Scotland REC 4
REC reference
16/WS/0024
Date of REC Opinion
14 Apr 2016
REC opinion
Further Information Favourable Opinion