Congenital CMR heartfunction Leeds (CoRaL)
Research type
Research Study
Full title
Advanced Cardiovascular Magnetic Resonance imaging biomarkers to assess cardiac function in congenital heart disease
IRAS ID
242212
Contact name
Malenka Bissell
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
A6-1
Congenital heart disease is an expanding specialty as the majority of children with congenital heart disease now survive well into adulthood. After initial surgical management in childhood many patients remain stable for a period of time, however further surgical interventions often become necessary throughout their life. Therefore monitoring of disease progression in all congenital heart disease patients throughout life is important. Early further surgical or catheter procedures to prevent irreversible damage are important. However, material used in these procedures such as heart valves have a limited life span and intervention timed too early generally leads to further operations, added risks and potential complications over the patients’ lifetime. Therefore careful timing of further treatment is essential. Cardiac magnetic resonance (CMR) is on the forefront of non-invasive surveillance in adult cardiology and is becoming more important in congenital heart disease as more advanced imaging options become available.
Another problem in paediatric cardiology is the increased incidence of obesity. Traditionally most CMR measures are related to body surface area to decide when treatment is indicated. This however becomes inaccurate in obese patients making it important to find body size independent imaging measurements to monitor heart function and the need for further treatment. We therefore aim to use new advanced MRI imaging techniques which are already researched and tested in adult cardiology and evaluate whether they also show early changes in congenital heart disease and could therefore be used to monitor heat function and disease progression in this patient group.REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
18/YH/0439
Date of REC Opinion
18 Dec 2018
REC opinion
Favourable Opinion