COMPRESS - COMPRession effect on Skin venous ulcer Surface oxygenation
Research type
Research Study
Full title
Study to assess the effect of compression on venous ulcer and skin surface oxygenation
IRAS ID
156201
Contact name
Paul Hayes
Contact email
Research summary
Tissue oxygenation plays a vital role in the healing process. It contributes to angiogenesis, the development of the extra-cellular matrix and cell motility within the wound healing process. Many wounds fail to heal because of inadequate oxygen levels.
Venous ulcers require multi-layer compression bandaging to reduce the effect of venous hypertension and tissue oedema in the area surrounding the ulcer. No documentation in the literature is present for the effect of multi-layer compression bandage on the oxygenation of the ulcer tissue or the skin surrounding it.
We are proposing a study to measure the oxygen saturation using a simple non-invasive laser doppler device to measure the ulcer tissue and the surrounding skin oxygenation with and without compression.
We are also going to measure the effect of topical oxygen dressing called Natrox oxygen delivery system with compression as a secondary objective.REC name
East of Scotland Research Ethics Service REC 2
REC reference
14/ES/1028
Date of REC Opinion
23 Jul 2014
REC opinion
Further Information Favourable Opinion