Complete arterial versus conventional coronary artery bypass grafting

• Research type

  Research Study

• Full title

  A retrospective, observational, single-centre study. Complete Arterial Revascularisation versus Conventional Coronary Artery Bypass Grafting in Multivessel Disease – Longitudinal Analysis of Ten-Year Outcomes

• IRAS ID

  181274

• Contact name

  Olaf Wendler

• Contact email

  olaf.wendler@nhs.net

• Sponsor organisation

  King's College Hospital NHS Foundation Trust

• Duration of Study in the UK

  0 years, 7 months, 1 days

• Research summary

  Coronary artery disease (CAD) is a condition where the blood supply to the heart vessels is impaired because of progressive calcification and therefore narrowing of the coronary vessels. Coronary artery bypass grafting (CABG) is the gold standard treatment for severe, ‘multivessel’ CAD. CABG is a procedure which helps re-supply sufficient amount of blood to the heart by replacing the narrowed blood vessel using an alternative vessel, called ‘graft’ or ‘bypass conduit’.

  The superiority of CABG over interventional treatment (stenting) in patients with severe CAD has been proven in various studies. It can be performed using various different bypass grafts, among these the left internal mammary artery (LIMA), which is most preferred. The LIMA is an artery that is located next to the sternum.

  In addition to the LIMA, others arteries such as the the right internal mammary artery (RIMA), the radial artery (RA) and a vein graft from the saphenous Vein ( Vein located in the leg), can be used to place as many by-passes as necessary.
  The advantage of different combinations of bypass grafts regarding long-term outcomes, either as complete arterial (LIMA-RIMA or LIMA-RA) or conventional (LIMA-SV) CABG, is still uncertain therefore the aim of this study is to assess long-term outcomes after CABG by comparison of complete arterial (LIMA-RIMA or LIMA-RA) to conventional (LIMA-SV) CABG. Outcome will be measured regarding survival, need for re-operation or re-intervention and symptom relief.

  Eligible patients will be simply asked to complete a questionnaire. There GP/cardiologist will also be contacted to obtain clinical data. Specifically to establish if the patient has had any heart operations after his/her CABG.

• REC name

  North East - Newcastle & North Tyneside 2 Research Ethics Committee

• REC reference

  15/NE/0306

• Date of REC Opinion

  26 Aug 2015

• REC opinion

  Favourable Opinion