Complement inhibitors in AAV
Research type
Research Study
Full title
Complement inhibitors in ANCA associated Vasculitis
IRAS ID
216135
Contact name
Neil Basu
Contact email
Sponsor organisation
NHS Grampian
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
ANCA associated vasculitis (AAV) is a disease of the immune system which affects multiple organs and can lead to death and serious morbidity. Advances in immune therapy have lead to substantial improvements in patient outcomes, however existing therapies do not help everyone and are associated with severe side effects. A better understanding of the precise mechanisms of this disease will support the development of more effective and safer therapies.
We have developed an in vitro model of AAV and now wish to investigate the role of the complement system - an important element of the immune system- in this model. To do this we will observe the effect of complement fragments and inhibitors on blood - sampled from AAV patients and healthy volunteers- using a 4D cellular microscope. The results of these experiments may lead to the application of complement targeted AAV therapies in the future.REC name
West of Scotland REC 5
REC reference
16/WS/0253
Date of REC Opinion
8 Dec 2016
REC opinion
Favourable Opinion