Complement activity in ANCA vasculitis
Research type
Research Study
Full title
Pilot study to assess the activation status of the complement system in blood from patients with anti-neutrophil cytoplasmic antibody (ANCA-) associated vasculitis
IRAS ID
150902
Contact name
Matthew D Morgan
Contact email
Sponsor organisation
Novartis Pharma AG
Clinicaltrials.gov Identifier
n/a, n/a
Research summary
The present research study will look at the way the complement system, an important part of the immune system, functions in people with vasculitis. Around 20 patients with vasculitis positive for the circulating antibody ANCA will take part in the study. Each patient will provide one blood sample for analysis of several complement components. The patients will be included before starting treatment, when stable in remission, or during flares of vasculitis. The aim of the research is to obtain data on the frequency of evidence of complement activation in vasculitis patients, and to evaluate the correlation of complement activation to disease-related clinical and/or laboratory parameters.
REC name
West of Scotland REC 5
REC reference
14/WS/1022
Date of REC Opinion
24 Jun 2014
REC opinion
Favourable Opinion