Comparison of SLP to X-Ray and Lung Function in Cystic Fibrosis
Research type
Research Study
Full title
Evaluation of Structured Light Plethysmography (SLP) as a method of recording disease severity in Cystic Fibrosis, using routine X-Ray scoring, and pulmonary function: A mulit-centre, prospective, cross-sectional study.
IRAS ID
165731
Contact name
Muhammad Irfaan Khan
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 8 months, 29 days
Research summary
Cystic fibrosis is a life-limiting chronic multisystem genetic disorder. Patients are reviewed by both X-Rays and Lung function atleast annually. Lung investigation and exposure to ionising radiation therefore begins from a young age, with increasing assessment depending on clinical status. SLP is a relatively new non-invasive and non-contact technology, with no known risks to health. A grid of visible light is projected from the PneumaCare Thora3Di device onto the thoracoabdominal wall, and two digital video cameras record changes in the grid pattern due to breathing motion. SLP is simple, quick, and easy to perform, usually taking 5 minutes. The study focuses on determining the extent to which SLP tidal breathing indices relate to X-Ray scoring and standard lung function testing. Associations may potentially reduce the frequency with which patients are subject to X-Ray radiation, and therefore decrease their risks of future malignancy. It may also be used as a support to lung function where patients are unable to obtain reliable or consistent information. Since lung function and X-Ray are already performed, the only addition to routine practice would be verbal and written consent, and performance of the 5 minute SLP. The test would be performed prior to standard breathing tests, with minimal impact on clinical time, and no change to hospital attendance.
REC name
East of England - Cambridge Central Research Ethics Committee
REC reference
15/EE/0202
Date of REC Opinion
11 Aug 2015
REC opinion
Further Information Favourable Opinion