ComparIsoN oF Optimal Hypertension RegiMens (AIM HY-INFORM )
Research type
Research Study
Full title
ComparIsoN oF Optimal Hypertension RegiMens (Part of the Ancestry Informative Markers in Hypertension (AIM HY) Programme – AIM HY-INFORM)
IRAS ID
199550
Contact name
Ian Wilkinson
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust and University of Cambridge
Eudract number
2016-000165-23
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
High blood pressure (hypertension) is extremely common and is a major cause of heart disease, kidney disease and stroke. One in three of the UK population will require treatment for hypertension at some point in their lives. A healthy lifestyle alone is often not enough to control blood pressure, and drug treatment is usually required. Although a wide variety of drugs are available to treat hypertension, choosing the right kind of tablet or combination of tablets for individual patients is a problem, and therefore many people have poor blood pressure control.
Hypertension treatment within the UK is currently selected according to age and self-defined ethnicity (SDE). There are limitations to this approach which include wide variability in the response to hypertension drug classes between people. There is also uncertainty about selecting hypertension drugs for ethnic minorities other than those of African/Caribbean ancestry, for example, South Asians because of a lack of information from trials. In the AIM HY-INFORM study we are looking to recruit an equal number of black African/Caribbean, South Asian and white European participants to be able to compare differences in hypertension treatments and ethnicity. In the first instance it is important to gain specific data on defined White, Black and Asian ethnic populations however, other ethnic groups or mixed ethnicity may be contacted for further studies in the future.
Overall, the study will try to define the best hypertension drug or drug combinations according to the three ethnic groups in the UK. The study will also help us to understand what sort of treatments and preventive measures are best for people of these different ethnicities.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
16/EE/0294
Date of REC Opinion
19 Oct 2016
REC opinion
Further Information Favourable Opinion