Comparison of MR elastography liver with and without navigator trigger
Research type
Research Study
Full title
A comparison of MR elastography of the liver using a standard breath-hold technique and Navigator-triggering.
IRAS ID
208333
Contact name
Paul Malcolm
Contact email
Sponsor organisation
Research and Development
Duration of Study in the UK
0 years, 11 months, 1 days
Research summary
This study is a comparison of MR elastography sequences which are used to determine how stiff liver tissue is. This has been shown to correlate well with the degree of stiffness (fibrosis/cirrhosis) seen on the results of liver biopsies. We will recruit patients from the liver outpatient clinic who have already had a liver biopsy showing fibrosis. They will be given an information letter at the outpatient appointment and will be contacted by the research team several days later to ask if they agree to participate in the study. The study will be conducted at Norfolk & Norwich University Hospital. The patients will have the elastography sequences added on to a routinely requested MR liver, which adds about ten minutes to the normal scan time. Written consent will be obtained immediately prior to the scan. The first elastography sequence is with the patient holding their breath (standard method), the second is using a “navigator“ sequence as a trigger which allows the patient to continue breathing normally throughout.
REC name
North West - Preston Research Ethics Committee
REC reference
16/NW/0840
Date of REC Opinion
21 Nov 2016
REC opinion
Favourable Opinion