Comparison of laboratory methods for detection of CipRE preTRUSB

• Research type

  Research Study

• Full title

  Comparison of laboratory methods for detection of antibiotic-resistant - Enterobacteriaceae through faecal screening of patients undergoing transrectal ultrasound guided prostate biopsy

• IRAS ID

  258932

• Contact name

  Mary Twagira

• Contact email

  m.twagira@nhs.net

• Clinicaltrials.gov Identifier

  N/A, N/A

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  Study Title: Comparison of laboratory methods for detection of antibiotic-resistant - Enterobacteriaceae through faecal screening of patients undergoing transrectal ultrasound guided prostate biopsy

  Infectious complication after prostate biopsy procedure has been on the increase. Standard antibiotics is given prior to the procedure but microorganisms in the gut have developed resistance to the common antibiotics .¹
  * Targeted prophylaxis has been recommended to identify patients who harbour Ciprofloxacin resistant enterobacteriaceae (CipRE) in their rectum before biopsy and offer them prophylaxis according to the antibiotic susceptibility pattern of their microbial flora.
  * Available studies are underpowered and have all used rectal swab for faecal screening prior to targeted prophylaxis ; this method has been unable to detect resistant organisms in the gut in 15% cases².
  * Currently there is inconsistency in the laboratory approaches for faecal screening prior to prostate biopsy

  This study aims to identify the most reliable, sensitive, specific, cost effective and rapid laboratory method for CipRE detection prior to TRUSB procedure which we can implement to reduce infectious complications and hospital readmission post biopsy

• REC name

  London - Riverside Research Ethics Committee

• REC reference

  19/LO/0233

• Date of REC Opinion

  20 Jan 2019

• REC opinion

  Favourable Opinion