Comparison of distal pancreatectomy fistula prediction models
Research type
Research Study
Full title
DISPAIR vs. D-FRS – establishing the superiority of the novel distal pancreatectomy pancreatic fistula risk prediction models – A multicenter international retrospective validation study
IRAS ID
321965
Contact name
Stephen J Wigmore
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
Fistula Risk Score (FRS) has been used in research surrounding resections of the head of pancreas. A prediction model for pancreatic fistula after resection of the tail and body of pancreas had long been warranted. This risk score could be used to predict the risk of serious complications associated with these distal pancreas resections and standardize models for future research.
Very recently, two distinct models – the DISPAIR and the D-FRS – which both included pancreas-specific measurements, were developed and validated. No studies comparing the performance of these models have been done, and superiority of one model over the other has not been established.
In this retrospective study we plan to gather a cohort of 200 patients, who have undergone a distal pancreatectomy in NHS Lothian. This data will then be pseudonymised and sent to Helsinki University Hospital, Finland without any personal data. Helsinki University Hospital researchers gather several international cohorts of distal pancreatectomies, because this operation is relatively rare and a large enough total cohort cannot be gathered from a single centre. The aim of this study is to compare and externally validate the performance of the DISPAIR and the D-FRS in a fully independent cohort of distal pancreatectomy patients. The ultimate goal is to establish the potential superiority of one model over the other and identify directions for potential model updating.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
23/WM/0017
Date of REC Opinion
16 Feb 2023
REC opinion
Further Information Favourable Opinion