Comparison of detergent sclerosants at timed intervals version 1
Research type
Research Study
Full title
In-vitro comparison of the effects of different concentration and exposure times of a detergent sclerosant (sodium tetradecylsulfate) on the human vein wall using histology and immunocytochemistry
IRAS ID
315791
Contact name
Mark Whiteley
Contact email
Sponsor organisation
The Whiteley Clinic
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
Abnormal veins causing varicose veins and venous leg ulcers need to be closed to cure the medical condition. Sclerotherapy is often used to close these veins by damaging the vein wall and closing the vein by ablating it.
Previous work has shown how 3% Sodium Tetradecyl Sulphate (STS) injected into an in-vitro human vein sample for 2 minutes causes necrosis of the whole vein wall.
This project aims to understand how 3% STS affects the vein wall at shorter and more clinically realistic times of wall contact.
In addition, we will examine the same substance with the same times of wall contact, but with a lower concentration of STS (1%).This will inform us as to whether lower concentrations are as effective as higher concentrations if left in contact for longer, or whether concentration is a determinant of the maximum damage that can be caused. Moreover, it will also indicate the optimal contact time for a sclerosant to cause significant damage to the vein wall.
These are very important factors to identify in improving sclerotherapy treatments for patients.REC name
Wales REC 7
REC reference
22/WA/0172
Date of REC Opinion
6 Jun 2022
REC opinion
Favourable Opinion