Comparison of detergent and osmotic sclerotherapy agents.
Research type
Research Study
Full title
In-vitro comparison of the action of detergent and osmotic sclerotherapy agents on the human vein wall using histological and immunocytochemical analysis of an explanted human vein.
IRAS ID
291854
Contact name
Mark Whiteley
Contact email
Sponsor organisation
The Whiteley Clinic
Duration of Study in the UK
0 years, 5 months, 3 days
Research summary
Abnormal veins causing varicose veins and venous leg ulcers need to be closed to cure the medical condition. Sclerotherapy is often used to close these veins by damaging the vein wall and closing the vein by ablating it.
This study aims to study the relative efficacies between the commonly used detergent sclerosants and the less commonly used, but safer, osmotic sclerosants using histology and immunocytochemistry of the vein wall.
If we can show that the safer osmotic sclerosants are as effective as the commonly used detergent sclerosants, we will be able to treat patients with venous disease as effectively but with a safer sclerotherapy agent.
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
20/SW/0184
Date of REC Opinion
8 Dec 2020
REC opinion
Favourable Opinion