Comparison of Cirrus OCT, RTVue OCT, MS-39 OCT and Insight 100 VHFDU
Research type
Research Study
Full title
Repeatability and reproducibility of Carl Zeiss Meditec Cirrus HD OCT 5000, Optovue RTVue OCT, CSO MS-39 OCT and ArcScan Insight 100 very high-frequency digital ultrasound and comparison between devices
IRAS ID
252319
Contact name
Mary Durbin
Contact email
Sponsor organisation
Carl Zeiss Meditec
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 6 days
Research summary
Accurate and repeatable measurements of the thickness of the cornea (the clear window at the front of the eye) are of great importance for many applications in ophthalmology, and for laser refractive surgery in particular. Recently, it has also become apparent that measuring the thickness of the corneal epithelium (the layer of skin on the surface of the cornea) is useful for screening before surgery and monitoring healing after surgery. The ability to image and measure the interfaces created within the cornea in a laser refractive surgery procedure is also important for monitoring safety and planning further treatments.
These measurements can be obtained either by very high-frequency (VHF) digital ultrasound or optical coherence tomography (OCT). VHF digital ultrasound has been used for this purpose for over 25 years, while OCT has been used for over 15 years. Recently, new versions of these devices have become available that have either improved or added the ability to measure epithelial thickness and interfaces within the cornea. These devices include the Insight 100 VHF digital ultrasound scanner, the Cirrus HD OCT 5000, the RTVue OCT, and the MS-39 OCT.
This study aims to evaluate the precision (repeatability and reproducibility) of these four devices and compare the measurements between devices. Specifically, the aims of the study are:
1) To report the repeatability and reproducibility of each device to understand the overall precision and therefore which applications each device can be reliably used for.
2) To report the comparison between each pair of devices to understand whether thickness measurements can be used interchangeably. This may be either within an individual patient who has been scanned on different devices at different time points, or to evaluate the results of studies where different devices have been used.
3) To investigate whether there was a systematic difference between VHF digital ultrasound and OCT measurements.REC name
London - Harrow Research Ethics Committee
REC reference
18/LO/1469
Date of REC Opinion
21 Dec 2018
REC opinion
Further Information Favourable Opinion