Comparative analysis of the use of three breath sampling devices
Research type
Research Study
Full title
Human factor comparative reliability analysis of the use of three devices for breath testing
IRAS ID
200423
Contact name
George Hanna
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
0 years, 7 months, 28 days
Research summary
Patients with oesophago-gastric (OG) cancer often present to clinicians with a spectra of non-specific symptoms. Alarming symptoms often indicate late and incurable disease. Consequently, in most cases the disease is picked up very late giving rise to poor prognosis figures particularly when compared to other cancers (the overall 5 year survival ranges from 20% to 30%). Prof. George Hanna’s team will apply mass spectrometry methods for the identification of cancer-specific metabolites associated with OG cancer with the long term aim of developing a non-invasive diagnostic breath test. The potential benefits for patients are earlier diagnosis in those presenting with soft symptoms, improved survival rates from earlier diagnosis, and better patient satisfaction due to the non-invasive nature of the test.
This study will explore the acceptability, and the process of use of devices for breath sampling on to adsorbent tubes: one device collects tidal breath, the other two are designed to concentrate forced exhalations. Analytical performance of the devices will be compared using thermal desorption coupled to gas chromatography mass spectrometry. This will help assess which device allows for the collection of more and higher levels of compounds.REC name
London - Queen Square Research Ethics Committee
REC reference
16/LO/1096
Date of REC Opinion
22 Jul 2016
REC opinion
Further Information Favourable Opinion