COMBINER

• Research type

  Research Study

• Full title

  The effectiveness of lithium plus quetiapine COMBination versus lithIum versus quetiapiNe monothErapy in the maintenance treatment of bipolar disordeR: the COMBINER trial.

• IRAS ID

  1010672

• Contact name

  Steven Marwaha

• Contact email

  s.marwaha@bham.ac.uk

• Sponsor organisation

  University of Birmingham.

• ISRCTN Number

  ISRCTN17178652

• Research summary

  COMBINER is a pragmatic, observer-blind, multi-centre, 3-arm, parallel group randomised controlled trial (RCT) with an internal pilot and full economic evaluation. The aim of the study is to evaluate the clinical and cost-effectiveness of combination lithium and quetiapine therapy compared with lithium or quetiapine alone for maintenance treatment in adults with bipolar disorder (BD).

• REC name

  North West - Haydock Research Ethics Committee

• REC reference

  25/NW/0087

• Date of REC Opinion

  18 Jun 2025

• REC opinion

  Further Information Favourable Opinion