COMBined phacovitrectomy, vs sequentiAl viTrectomy & cataract surgery
Research type
Research Study
Full title
Clinical and cost-effectiveness, safety, and acceptability of COMBined phacovitrectomy, versus sequentiAl viTrectomy and cataract surgery, for the management of rhegmatogenous retinal detachment: A Randomised Equivalence Clinical Trial
IRAS ID
338079
Contact name
Noemi Lois
Contact email
ISRCTN Number
ISRCTN13728688
Duration of Study in the UK
3 years, 5 months, 31 days
Research summary
The retina is the layer at the back of the eye that gives sight. Normally it is attached to the wall of the eye, but can separate in a condition called rhegmatogenous retinal detachment(RRD). RRD causes sight loss and requires surgery.
The most common surgery to treat a RRD is Vitrectomy however, Vitrectomy can have complications. The most common is cataracts which get worse with time. When they affect vision they need to be removed with surgery. In cataract surgery the foggy lens is changed (replaced) for an artificial clear lens.
Surgeons do not routinely offer cataract surgery at the same time as vitrectomy in people with RRD. At the moment, we don‘t know if it‘s best to do both surgeries at the same time or separately. Thus, we planned COMBAT. Patients who join COMBAT will receive either 1) vitrectomy first and, if needed, cataract surgery later, or 2) cataract surgery and vitrectomy at the same time.
We will compare how people do by looking at their sight, the number of retinas that reattach, patient satisfaction, complications and costs.REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
25/YH/0056
Date of REC Opinion
21 Mar 2025
REC opinion
Favourable Opinion