Collection of joint mesenchymal stem cells (MSCs)
Research type
Research Study
Full title
Collection of joint Mesenchymal Stem Cells by aspiration, biopsy, joint retrieval at arthroplasty or by synovium agitation during arthroscopy.
IRAS ID
100077
Contact name
Dennis McGonagle
Contact email
Sponsor organisation
University of Leeds
Research summary
The overarching theme of this work is to better understand the biology of Stem Cells in the joint, as a prerequisite for developing novel treatments for Osteoarthritis. Osteoarthritis is a condition that affects approximately 20% of adults between the ages 45–64 years within the UK. Vast osteoarthritis are invariably associated with loss of articular surfaces which is associated with progressive pain, and disability, may ultimately require joint replacement. For older patients with end stage Osteoarthritis, joint replacement is very effective. However this is not usually used in younger patients. We have previously discovered Stem Cells in synovial fluid (Jones et al 2004, Jones et al 2008), however on-going research at the NIHR, and by the wellcome trust EPSRC, is attempting to develop novel Stem Cells based strategies for joint repair in younger subjects.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
14/YH/0087
Date of REC Opinion
14 Apr 2014
REC opinion
Further Information Favourable Opinion