Cohort study investigating haemophilic arthropathy development V0.01
Research type
Research Study
Full title
Evaluation of the Effect of Musculoskeletal and Exercise Factors on the Development of Joint Disease in Haemophilia.
IRAS ID
159597
Contact name
Ann McCarthy
Contact email
Sponsor organisation
University of Brighton
Duration of Study in the UK
2 years, 2 months, 31 days
Research summary
Haemophilia is an inherited blood clotting disorder where the clotting factors that normally occur in the circulation are at a low level of absent so that when bleeding occurs, it does not stop. The most common site for bleeding is into the ankle joint. if this happens repetitively, then the joint becomes permanently damaged, painful and restricted. Treatment to replace clotting factors is not 100% effective in all people and so damage continues to occur. A previous consensus survey of expert clinicians has developed a list of possible factors that might influence the development of this joint damage. This survey has confirmed that clinicians believe that the origin of joint damage is multifactorial.
The study aims to look for a number of these factors in several groups. These groups are people with and without haemophilia, and with and without ankle joint problems. It is important to use these four groups so that we can be sure that any positive findings are specifically related to the ankle joint problems and not the haemophilia. We will look for the factors using a combination of simple clinical tests and surveys. Once all the data has been collected statistical analysis called regression analysis will allow us to see which factors are most strongly linked to the presence of ankle joint problems in haemophilia.REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
14/EE/1137
Date of REC Opinion
24 Sep 2014
REC opinion
Further Information Favourable Opinion