Cohort-NHS V1
Research type
Research Study
Full title
Study of imaging and molecular biomarkers in uncomplicated rhegmatogenous retinal detachment.
IRAS ID
355666
Contact name
James Bainbridge
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2025/05/174, UCL DPO
Duration of Study in the UK
0 years, 6 months, 0 days
Research summary
Why this research study?
This is a study of patients with primary rhegmatogenous retinal detachment to assess the risk of recurrent retinal detachment following surgery due to a complication called proliferative vitreoretinopathy (PVR). PVR is scarring of the retina following this primary surgery which occurs in approximately 15-20% of the patients. We are looking to develop a risk model based on imaging and molecular analysis of the vitreous fluid (without PVR) to predict risk of recurrence secondary to PVR.
Above will guide future treatments for PVR and further identify high risk populations not just from a clinical perspective but with the utilisation of their imaging and molecular biomarkers.What does the research study involve?
Participants we will have various non-invasive imaging of their retinal detachment at the Moorfields clinical research facility and during the surgery an extra step will be carried out to retrieve a small, up to 0.5ml of the vitreous fluid that is otherwise discarded at the time of the surgery. Previous literature has not shown additional risks to the surgery described that will involve this extra step.
Research actvities will be with the research team at the Moorfields Clinical Research Facility following timely appointments and mirroring standard of care time points.Who is eligible for this research study?
Participants with ‘uncomplicated’ retinal detachment without PVR scar tissue, and are due to undergo surgery to treat this.Where will this research study take place?
The study will take place at Moorfields Eye Hospital and laboratory and imaging analyses will be carried out at the UCL Institute of Ophthalmology.How long will this research study last?
Study participation will mirror standard of care and follow-up of 3 months and this will include approximately 5 hospital visits, including the date of your surgery. Additional visits will be arranged if any issues in patient's best interests.REC name
London - Harrow Research Ethics Committee
REC reference
26/LO/0145
Date of REC Opinion
19 Mar 2026
REC opinion
Further Information Favourable Opinion