COgnitive Monitoring for Planned Arthroplasty Surgery Study (COMPASS)
Research type
Research Study
Full title
COgnitive Monitoring for Planned Arthroplasty Surgery Study (COMPASS)
IRAS ID
214288
Contact name
Johannes Retief
Contact email
Sponsor organisation
University Hospitals Plymouth NHS Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
A decline in cognitive (thinking and memory) function is common and sometimes permanent following major surgery in the elderly. However, it is incompletely understood. It is uncertain what causes the change, whether a similar decline might occur without surgery and who is at risk. Current literature lacks an accurate picture of pre-operative cognitive trajectories and trajectories in older people who don’t have surgery (an appropriate control group).
Cognitive Monitoring in Planned Arthroplasty Surgery Study (COMPASS) is a collaboration between trainee-led research networks, patients, psychology and dementia experts and industry. CogTrack™ is an online, self-administered, battery of tests performed in about 20 minutes and is validated for serial remote cognition monitoring in elderly patients. Our aim is to assess the feasibility of serial remote monitoring of cognition with CogTrack™ in patients over 60 undergoing planned hip and knee joint replacements and matched non-surgical controls. Serial cognitive testing (five occasions) will be performed on 150 surgical patients and 50 matched non-surgical controls over an 11 week window (incorporating the surgical episode in the operated group).
This is a feasibility study at two secondary care sites and three primary care sites. We will check the accessibility and fidelity of our methodology in our target population and test our plan of investigation and available resources. Patients were involved in refining outcome measures and will contribute throughout.
Using lessons learnt and pilot data, our aim is a future multi-centre study to track the cognitive trajectories of large numbers of operated cases and matched controls over a long time period. Arthroplasty (joint replacement) surgery is common and aims to improve quality of life. However, permanently altered cognition could negatively impact on patients’ quality of life so it is important to study whether this phenomenon is real.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
18/SC/0329
Date of REC Opinion
31 Jul 2018
REC opinion
Further Information Favourable Opinion