Cognitive impairment in cerebrovascular disease

• Research type

  Research Study

• Full title

  Understanding factors affecting cognitive function in cerebrovascular disease

• IRAS ID

  299333

• Contact name

  Fatemeh Geranmayeh

• Contact email

  fatemeh.geranmayeh00@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Duration of Study in the UK

  10 years, 0 months, 0 days

• Research summary

  Cognitive impairment is common in patients with cerebrovascular disease (CVD) affecting up to 85% of patients following acute stroke. It can manifest in difficulties with numerical, visual and linguistic processing, attention, memory, planning and reasoning, with a variable and unpredictable trajectory. Understanding the range of factors that contribute to cognitive recovery after stroke is a large unmet need.

  The aims of the study are to
  1. Develop and validate an automated, computer based, remote cognitive assessment tool that allows frequent and longitudinal monitoring of cognitive functions in the home setting. This will allow us to map the trajectory of the patient’s cognitive function over a 3-year period.
  2. Predict the cognitive trajectory based on several premorbid, stroke related, and post-stroke factors including:
  i) brain and retinal imaging to assess microvascular integrity
  ii) blood biomarkers of neurodegeneration and neuroinflammation
  iii) comorbid physical and psychological factors

  Patients with stroke will be recruited from the local hyperacute and acute stroke units, and those at high risk will be recruited from TIA, memory, stroke and hypertension clinics at Imperial College Healthcare NHS Trust with potential to expand recruitment to other NHS and Primary Care Trusts subject to regulatory approval. Age-matched healthy participants will be recruited to validate the remote computer based cognitive tool, as well as imaging and blood biomarkers.

  This study will improve the assessment of cognitive functions in patients with CVD. The results of the study will enhance our understanding of the range of factors that contribute to cognitive recovery in CVD. It will enable a more personalised approach to targeting of cognitive rehabilitation to those that are both most at risk of progressive cognitive decline and have the greatest potential for recovery.
  

• REC name

  South West - Frenchay Research Ethics Committee

• REC reference

  21/SW/0124

• Date of REC Opinion

  7 Oct 2021

• REC opinion

  Further Information Favourable Opinion